Protein Kinase C« Regulates Proliferation and Cell Sensitivity to TGF-1b of CD4 T Lymphocytes: Implications for Hashimoto Thyroiditis
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منابع مشابه
Protein kinase Cε regulates proliferation and cell sensitivity to TGF-1β of CD4+ T lymphocytes: implications for Hashimoto thyroiditis.
We have studied the functional role of protein kinase Cε (PKCε) in the control of human CD4(+) T cell proliferation and in their response to TGF-1β. We demonstrate that PKCε sustains CD4(+) T cell proliferation triggered in vitro by CD3 stimulation. Transient knockdown of PKCε expression decreases IL-2R chain transcription, and consequently cell surface expression levels of CD25. PKCε silencing...
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تاریخ انتشار 2011